Search for secretion-where is the way to male contraception?

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The team developed a soluble adenylate cyclase (sAC) inhibitor, TDI-11861, which temporarily reduced sperm motility without affecting sperm quality in mice. A single injection of TDI-11861 (50 mg/kg) can stably inhibit the sperm motility of male mice for up to 2.5 hours, and TDI-11861 has no effect on the ejaculation ability of male mice. The team hopes to develop a modified sAC inhibitor suitable for human clinical trials within 2-3 years. At present, apart from condoms, there is really no male contraceptive method that has these two advantages. "A lot of previously promising male contraceptive research work has been interrupted for a variety of reasons. After all, the consequences of accidental pregnancy and the harm to the body are often borne by the woman? However, female contraceptives, whether it is tubal ligation, Anjie ring or oral hormone drugs will bring certain side effects.


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Whether or not to take contraceptive measures and what kind of contraceptive measures are, in the final analysis, a choice for individuals, partners and even families.


RecentlyNature CommunicationsAn article "On-demand male contraception via acute inhibition of soluble adenylyl cyclase" published in the journal[1]Attracted widespread attention on social media, the topic of "male contraceptive" entered the hot search list of Weibo, and medical experts from domestic and foreign academic circles also joined the discussion one after another.


In this study, the team developed a soluble adenylate cyclase (sAC) inhibitor TDI-11861.We know that in the process of conception, sperm usually need to start from the vagina, struggle to swim into the uterus, fallopian tubes, after a long journey to meet the egg. On the other hand, the drug can temporarily reduce sperm motility without affecting the sperm quality of mice, just like silencing the referee's starting gun before the game, but the energetic athletes did not receive the match signal after playing, thinking that the game was cancelled. so stand by or rely on inertia to walk two steps and lie down to rest.


The results showed that a single injection of TDI-11861 (50 mg/kg) could stably inhibit the sperm motility of male rats for 2.5 hours. None of the 52 pairs of mice became pregnant from 30 minutes after injection to 2.5 hours after injection (that is, 2 hours paired), and the contraceptive rate was 100%, while the pregnancy rate of mice in the solvent control group was 30%. There was no significant change in sexual behavior between the two groups, and TDI-11861 had no effect on the ejaculation ability of male mice. And 24 hours after TDI-11861 injection, the fertility of male rats returned to normal.


The data also show that TDI-11861 can achieve the same effect as injection by oral administration, and there are no short-term and long-term side effects. The research team hopes to develop improved sAC inhibitors suitable for human clinical trials within 2-3 years.


Why can a study that is still in the experimental stage of mice cause such a sensation? The combination of "non-hormonal contraception" and "on-demand contraception", apart from condoms, there is really no male contraceptive method with these two advantages, so the research and development results of TDI-11861 have attracted a lot of attention.


But the drug may still have a long way to go before it is truly successful in research and development-it is approved to go on the market and put into use.The drug development cycle is long, and many previously promising male contraceptive research work has been interrupted for a variety of reasons, such as gossypol.[2]Testosterone undecanoate[3]Wait.



Search for secretion-where is the way to male contraception?

What contraceptive measures should be recommended at present? This leads to another question: who uses contraception?


Usually women are more concerned about this. After all, the consequences of unintended pregnancy and the harm to the body are often borne by the woman. However, female contraceptive methods, whether tubal ligation, Anjiu ring or oral hormone drugs, will bring certain side effects, which will be more expensive than male contraception.[4]. With the development of the times, more and more men realize that contraception is the responsibility of both parties and are willing to take contraceptive measures.


Here are some common male contraceptive methods[4] [5] [6]:


Sometimes contraception is not to avoid having children, but to avoid unwanted pregnancy. It is also good for the next generation to prepare for pregnancy in a planned and prepared state.


Whether or not to take contraceptive measures and what kind of contraceptive measures are, in the final analysis, a choice for individuals, partners and even families. I hope everyone will make their own choices on the basis of full understanding, and be responsible for themselves and their partners.


Introduction to the column

Popular science propaganda and health education are the key strategies for disease prevention. Since its establishment, the official account of Mimaitong Urology has always carried out the original intention and mission of "creating professional medical achievements to make society better". In order to respond to the needs of readers and promote scientific, practical and easy-to-understand knowledge of urology, a popular science column named "search and secretion" is added, which means "searching for knowledge of urology". We expect it not only to answer patients' questions, but also to provide convenient knowledge tools for clinicians' popular science education. Readers are welcome to leave messages to inform us of urology-related issues of concern in clinical and daily life, to help us "think about what patients think and what patients are urgent". We also hope that readers will actively contribute to the prosperity and development of urology.


References:

[1] Balbach M, Rossetti T, Ferreira J, et al. On-demand male contraception via acute inhibition of soluble adenylyl cyclase. Nat Commun. 2023: 14 (1): 637. Published 2023 Feb 14.

[2] Zheng Shujie. The rise and fall of gossypol contraceptive Research in China [D]. University of Chinese Academy of Sciences, 2014.

Zhao Xiaoming, Zhu Huibin, Zhuang Liuqi. Clinical research status of steroid contraceptive in men [J]. Foreign Medicine (Family Planning fascicles), 2001 Journal 20 (2): 79-83.

[4] https://www.mayoclinic.org/zh-hans

Long Qian, Li Li, Yue Jinchun, et al. Investigation on surgical attitude and causes of contraceptive failure in unmarried women with induced abortion [J]. Qilu Journal of Nursing, 2013 Jing 19 (16): 64-65.

Liu Fangwei, Xiong Shimin, Zhou Yuanzhong, et al. Male vasectomy and postoperative safety [J]. Guangdong Medicine, 2017, 38 (20): 3210-3212, 3218.


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